目的:探讨腹腔镜与经腹子宫全切术对机体免疫功能的影响。方法:选择70例有子宫全切除术适应证的患者,随机分为腹腔镜子宫全切术组(TLH组)和开腹子宫全切术组(TAH组),每组各35例,比较两组患者围手术期指标及手术前后C-反应蛋白(CRP)、T淋巴细胞亚群的动态变化。结果:TLH组术中出血量及术后肛门排气时间均显著少于TAH组(P<0.05);TLH组术后各时间点CRP水平均明显低于TAH组(P<0.05);TAH组患者CD3+、CD4+、CD4+/CD8+水平在术后1天和3天均较术前明显降低(P<0.05),且低于TAH组(P<0.05);TLH组术后免疫功能各指标与术前相比差异无统计学意义(P>0.05)。结论:腹腔镜子宫全切术具有机体创伤小、应激反应小、对免疫功能影响小及术后恢复快的优点,值得临床进一步推广应用。 Objective: To investigate the effect of laparoscopy and abdominal hysterectomy on immune function. Methods: Totally 70 patients with hysterectomy indications were randomly divided into laparoscopic total hysterectomy group (TLH group) and open hysterectomy group (TAH group), 35 cases in each group, compared with two The perioperative indexes and the changes of C-reactive protein (CRP) and T lymphocyte subsets in the patients before operation were analyzed. Results: The amount of bleeding and time of postoperative anal exhaust in TLH group were significantly less than those in TAH group (P <0.05). The levels of CRP in TLH group were significantly lower than those in TAH group at each time point (P <0.05) The levels of CD3 +, CD4 + and CD4 + / CD8 + in patients with TLH were significantly lower than those preoperatively (P <0.05) and lower than those of TAH at 1 and 3 days after operation (P <0.05) Before the difference was not statistically significant (P> 0.05). Conclusions: Laparoscopic hysterectomy has the advantages of less organ trauma, less stress response, less impact on immune function and quick recovery after operation. It is worth further clinical application.