我们遇到氨苄青霉素引起过敏性休克4例(男1例,女3例),年龄28～63岁。肺部感染2例,泌尿系及胆系感染各1例。既往均无青霉素过敏史。发生过敏性休克后,经注射肾上腺素、地塞米松等抢救成功3例,1例死亡。讨论:氨苄青霉素为半合成青霉素,因与蛋白结合率(约24%)低于其他青霉素类药,故过敏反 We encountered four cases of ampicillin-induced anaphylactic shock (1 males and 3 females), aged 28 to 63 years. 2 cases of pulmonary infection, urinary tract and gall bladder infection in 1 case. No past history of penicillin allergy. After anaphylactic shock, three cases were successfully treated by epinephrine injection and dexamethasone, and one case died. Discussion: Ampicillin is a semi-synthetic penicillin, because the protein binding rate (about 24%) is lower than other penicillins, so allergic