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美国FDA发出警戒称:当辛伐他汀与胺碘酮联合应用时,有增加横纹肌溶解症(RML)的危险性。这一危险性的存在与剂量有关,当辛伐他汀的剂量超过20mg·d~(-1),并同时使用了胺碘酮即极易引发RML。虽然在2002年的说明书上
The US FDA warned that there is a risk of increasing rhabdomyolysis (RML) when simvastatin is used in combination with amiodarone. The existence of this risk and dose, when the dose of simvastatin over 20mg · d ~ (-1), and the simultaneous use of amiodarone is extremely easy to trigger RML. Although in the 2002 manual