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托美汀(tolmetin,1)、萘普生(2)和类似非甾体抗炎药的原合成路线步骤多或使用昂贵且不易获得的特殊试剂。本文使用对甲苯磺酰甲基异氰化物(p-CH3C6H4SO2CH2N=C,TOSMIC)经一步反应有效方便地制备了1和2的关键合成中间体,即1-甲基-5-(4-甲苯酰基)吡咯-2-乙腈(3)和
The original synthetic routes of tolmetin (1), naproxen (2) and similar non-steroidal anti-inflammatory drugs have many or many special reagents that are expensive and not readily available. In this paper, 1-methyl-5- (4-toluoyl) -2-methyl-4-methylbenzoyl isocyanide (p-TMSMH4SO2CH2N = ) Pyrrole-2-acetonitrile (3) and