大黄素存在于虎杖、大黄、首乌、决明子等多种中草药中，有抗癌、抗菌、利尿、免疫抑制和舒张血管作用，也有致突变的报道。本实验用HPLC法测定大黄素在兔体内的绝对生物利用度和蛋白结合率。将2～3kg重雄性新西兰大兔分为2组，每组6只，给药前24h禁食，照常饮水，肌注开他敏（ Emodin exists in many kinds of Chinese herbal medicine such as Polygonum cuspidatum, rhubarb, Shouwu, cassia seed, and has anti-cancer, antibacterial, diuretic, immunosuppressive, and vasodilating effects, but also reported mutagenesis. In this experiment, the absolute bioavailability and protein binding rate of emodin in rabbits were determined by HPLC. 2 to 3 kg male New Zealand rabbits were divided into 2 groups, 6 in each group, 24 h before administration, fasting, drinking water as usual, and intramuscular injection of ketamamine (