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目的 研究糖尿病腹泻患者血清胃泌素、血浆胃动素、生长抑素水平的变化及其临床意义。方法 应用放射免疫法测定 78例糖尿病腹泻患者血清胃泌素、血浆胃动素、生长抑素水平 ,2 2例年龄性别相匹配的健康志愿者作为正常对照。结果 糖尿病腹泻患者血清胃泌素、血浆胃动素较正常对照组相比有明显升高 (P <0 .0 5 ) ;血浆生长抑素与正常对照组相比有明显降低 (P <0 .0 5 ) ;空腹血糖与血清胃泌素、血浆胃动素水平呈直线正相关 (P均 <0 .0 5 ) ,与血浆生长抑素呈直线负相关 (P <0 .0 5 ) ;血清胃泌素、血浆胃动素随着病程的延长略有升高趋势 ,生长抑素随着病程的延长略有下降趋势 ,但统计学分析差异无显著性 (P均 >0 .0 5 ) ;血清胃泌素、血浆胃动素水平升高与生长抑素水平降低呈直线负相关 (P <0 .0 5 )。结论 糖尿病性腹泻患者血清胃泌素、血浆胃动素水平升高 ,生长抑素水平降低 ,可能与高血糖时可使生长抑素分泌减少 ,从而减弱了生长抑素对胃泌素、胃动素分泌的抑制作用以及糖尿病植物神经功能病变等因素有关
Objective To study the changes of serum gastrin, plasma motilin and somatostatin in patients with diabetic diarrhea and its clinical significance. Methods Serum gastrin, plasma motilin and somatostatin levels were measured in 78 diabetic patients with diarrhea by radioimmunoassay. Twenty-two healthy volunteers were selected as normal controls. Results Serum gastrin and plasma motilin in diabetic patients with diarrhea were significantly higher than those in normal controls (P <0.05). The plasma somatostatin levels were significantly lower than those in normal controls (P <0.05). There was a linear positive correlation between fasting plasma glucose and serum gastrin and plasma motilin (P <0.05), but negatively correlated with plasma somatostatin (P <0.05). Serum Gastrin and plasma motilin increased slightly with the course of disease. Somatostatin decreased slightly with the prolongation of disease course, but there was no significant difference in statistical analysis (P> 0.05). Serum gastrin, plasma motilin levels and somatostatin levels decreased a negative linear correlation (P <0. 05). Conclusion Serum gastrin, plasma motilin and somatostatin levels in patients with diabetic diarrhea may be decreased, which may be related to the decrease of somatostatin secretion in hyperglycemia, which may reduce the effect of somatostatin on gastrin, gastric motility Inhibition of hormone secretion and diabetic autonomic dysfunction and other factors