论文部分内容阅读
新生儿红斑狼疮(neonatal lupus erythematosus,NLE)为1954年由Mccuistion等记述的疾病。见于患有系统性红斑狼疮和其他胶原疾病的母亲所生的新生儿,其临床症状是一过性的园盘状狼疮样皮疹或环形红斑,有时合并贫血、白细胞和血小板减少、肝脏肿大及心脏疾患等,并认为NLE的发病与通过母亲的胎盘(IgG)有关,其抗体多为SS-A/R_0抗体。一般认为,来自母亲的抗体消失为止的新生儿期及乳儿期的NLE,其临床经过是一过性的,但报道伴有不可逆心疾患的病例相当多,在当时或数年后可转变为系统红斑狼疮,且预后不良。为弄清本症实际情况,作者采用了咨询的方式,对全国大学病院的皮肤科和小儿科共60例患儿进行了研究。
Neonatal lupus erythematosus (NLE) is a disease described by Mccuistion et al in 1954. Found in newborns born to mothers with systemic lupus erythematosus and other collagen diseases, the clinical symptoms are transient Parkinson-type rash or annular erythema, sometimes with anemia, leukopenia and thrombocytopenia, enlarged liver and Heart disease, etc., and that the incidence of NLE through the mother’s placenta (IgG), and its antibodies are mostly SS-A / R_0 antibody. It is generally accepted that the clinical course of neonatal and neonatal NLE until the disappearance of antibodies from mothers is transient, but there are quite a number of cases reported with irreversible heart disease that could be transformed into systems at that time or years later Lupus, and poor prognosis. To clarify the actual situation of the disease, the author used a consultation approach, the National University Hospital dermatology and pediatrics a total of 60 cases of children were studied.