顽固性腹水又称难治性腹水,是指患者经正规利尿剂治疗6周、腹水仍无明显消退或加重的一种腹水状态[1]。它是肝病晚期常见的严重并发症之一。患者因大量腹水,生存质量差,往往死于腹水感染、肝肾综合征或肝性脑病,不能及时有效调整利尿剂和控制钠、水摄入等医源性因素是临床不容 Refractory ascites, also known as intractable ascites, refers to patients with formal diuretics for 6 weeks, ascites still no significant regression or worsening of an ascites state [1]. It is one of the most common serious complications of late liver disease. Patients due to a large number of ascites, poor quality of life, often died of ascites infection, hepatorenal syndrome or hepatic encephalopathy, not timely and effective diuretics and control of sodium, water intake and other iatrogenic factors are not clinical