1980年,Lim Vs等人就指出,慢性肾衰病人伴有性腺受损和不育提示下丘脑——垂体——性腺轴的功能紊乱。Olgaard等人报告,血透不能改善这种功能异常。1984年,Hayslett和Paul等人报告了数例肾移植后妇女成功地获得了妊娠和分娩。为了评价成功的肾移植后男女垂体激素和性激素状态与生育力的关系,以及判断基础激素水平和妊娠的关系, In 1980, Lim Vs et al. Pointed out that patients with chronic renal failure accompanied by gonadal injury and infertility suggest dysfunction of the hypothalamus-pituitary-gonadal axis. Olgaard et al reported that hemodialysis can not improve this dysfunction. In 1984, Hayslett and Paul et al. Reported on the successful gravitation and childbirth of several women after kidney transplantation. In order to evaluate the relationship between male and female pituitary and sex hormone status and fertility after renal transplantation and to determine the relationship between basal hormone levels and pregnancy,