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系统性红斑性狼疮(SLE)是当前皮肤科和内科重点研究的课题之一。在系统性红斑性狼疮的发病中,出现免疫学紊乱,血管病变和组织损伤,这三者密切相关。DNA抗体和抗DNA抗体组成循环免疫复合物,沉积于血管壁,造成了血管和组织损伤,血管病变在这三者中处于中介环节,因而日益受到重视。近年来国内外一些作者应用微循环观察技术,通过活检微循环观察SLE的血管变化,发现SLE患者的微循环均有各种不同程度的障碍,也观察到微循环障碍与SLE患者免疫学紊乱也有一定关系。例如Mach等(1979)曾指出SLE患者肾脏受累时,皮肤血液循环减
Systemic lupus erythematosus (SLE) is currently the focus of dermatology and medical research topics. In the pathogenesis of systemic lupus erythematosus, immunological disorders, vascular lesions and tissue damage, the three are closely related. DNA antibodies and anti-DNA antibodies form a circulating immune complex, deposited in the blood vessel wall, causing blood vessels and tissue damage, vascular disease in the three are in the intermediate links, and thus has received increasing attention. In recent years, some authors at home and abroad use microcirculation observation technology to observe the vascular changes of SLE by biopsy microcirculation and found that microcirculation of SLE patients have various degrees of disorder, and immunological disorders of microcirculation disorder and SLE patients are also observed A certain relationship. For example, Mach et al. (1979) pointed out that when the kidneys of SLE patients are involved, the skin blood circulation is reduced