论文部分内容阅读
为了解具有家族背景大肠癌微卫星不稳定性（ＭＩＮ）及其与临床病理表现的关系，应用银染聚合酶链反应－单链构相多态性（ＰＣＲ－ＳＳＣＰ）分析技术，对４６ 例大肠癌进行研究。结果：ＭＩＮ在具有家族背景大肠癌中的表达明显高于无家族史的散发性大肠癌（Ｐ＜ ０．０５）。癌家族史、ＭＩＮ 的表达与大肠癌发病年龄轻、右半大肠癌、大肠外癌及低分化癌的发生率高均有明显关系（Ｐ＜ ０．０１，Ｐ＜ ０．０５），而与多原发癌的发生及转移复发无明显关系（Ｐ＞ ０．０５）。说明ＭＩＮ在具有家族背景大肠癌中起着明显的作用。ＭＩＮ 阳性和家族背景大肠癌具有发病年龄轻、右半大肠癌、伴大肠外癌及低分化癌的发生率高的表现
To understand the relationship between family background microsatellite instability (MIN) and its clinicopathological features in colorectal cancer, a silver staining polymerase chain reaction-single-stranded constitutional polymorphism (PCR-SSCP) analysis technique was used in 46 cases. Colon cancer research. Results: The expression of MIN in colorectal cancer with family background was significantly higher than that of sporadic colorectal cancer without family history (P<0.05). The family history of cancer, the expression of MIN was significantly associated with the age of onset of colorectal cancer, the incidence of right colon cancer, large out-of-colode cancer, and poorly differentiated carcinoma (P<0.01, P<0.05). There was no significant relationship between the occurrence and metastasis of multiple primary cancers (P> 0.05). This shows that MIN plays a significant role in the family background of colorectal cancer. MIN positive and family background colorectal cancer has a high incidence of mild onset, right colorectal cancer, large extra-intestinal cancer, and poorly differentiated cancer