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1888年Zeigler首先报告了非细菌性血栓性心内膜炎(NBTE),描述了纤维蛋白在心脏瓣膜上的沉积,命名为血栓性心内膜炎,认为是由血液中微血栓沉积于正常的或表面变性的瓣膜所致.直至1954年,Angrist和Marquiss提出了此病常发生体动脉栓塞后才广为重视,确定了临床意义,并发现NBTE并非唯一发生于癌肿或消耗性疾病的病人.随着新的无创性检查技术的问世,本病的生前诊断才有很大的可能性.流行病学尸解发现,约1.2%(0.3～9.3%)病例的赘生物由NBTE所致.Rosen和Armstrong
In 1888 Zeigler first reported non-bacterial thrombotic endocarditis (NBTE), describing the deposition of fibrin on heart valves, termed thrombotic endocarditis, believed to be caused by the deposition of micro-thrombi in the bloodstream on normal Or surface degeneration of the valve caused by up until 1954, Angrist and Marquiss proposed this disease often take place after the importance of body embolism, to determine the clinical significance and found that NBTE is not the only cancer or wasting disease in patients With the advent of new noninvasive techniques, prenatal diagnosis of this disease is very likely. Epidemiological autopsy found that about 1.2% (0.3 to 9.3%) of the cases of neoplasm caused by NBTE. Rosen and Armstrong