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目的：研制一个理想的脊髓损伤动物模型。方法：利用杠杆原理设计了大鼠Ｔ１３ 脊髓腹侧压迫模型，为了验证其稳定性，本研究将４０ 只大鼠随机分为６ 组：对照组、假手术组、３４－５ｇ 压迫１ ｍｉｎ 组、３４－５ｇ 压迫４ ｍｉｎ 组、３４－５ｇ 压迫８ ｍｉｎ 组、固定脊柱再以３４－５ｇ 压迫４ ｍｉｎ 组，于伤后每天观察倾斜平面临界角，２ 周观察神经功能评分，并观察了３４－５ｇ压迫８ ｍｉｎ 组伤后３０ ｍｉｎ 、１ｈ 、４ｈ 、２４ｈ 、２ 周的组织学特点。结果和结论：该模型具有可重复性、可定量、模拟临床、简便易行、经济易取等优点。
Objective: To develop an ideal animal model of spinal cord injury. Methods: The model of ventral compression of T13 spinal cord was designed by using lever principle. In order to verify its stability, 40 rats were randomly divided into 6 groups: control group, sham operation group, 34-5g compression 1 min group, 34-5g oppression for 4 min group, 34-5g oppression for 8 min group, fixed spinal column and 34-5g oppression for 4 min group. The critical angle of oblique plane was observed every day after injury, neurological function score was observed for 2 weeks, and 34- The histological features at 5 min after compression for 8 min were 30 min, 1 h, 4 h, 24 h and 2 wk respectively. RESULTS AND CONCLUSION: The model has the advantages of repeatability, quantification, clinical simulation, simple and easy to use, economical and easy to take.