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目的:对临床输注条件下核黄素磷酸钠的光稳定性进行分析探讨,为今后的临床输注工作提供可靠的参考依据。方法:将核素磷酸钠经浓度为0.9%的氯化钠注射液进行配伍,分别在避光条件下和模拟临床非避光条件下0、1、2、4、8、24小时时经高效液相色谱法进行含量测定,并对比分析不同条件下、不同时间段的测定结果。结果:避光条件下核黄素磷酸钠24小时内稳定,在模拟临床非避光条件下随着时间的增加配伍液逐渐降解。结论:核黄素磷酸钠对光不稳定,临床输注过程中应注意,采取有效的避光措施,以提高输注质量。
OBJECTIVE: To analyze and discuss the light stability of riboflavin sodium phosphate under the condition of clinical infusion, and provide a reliable reference for future clinical transfusion. Methods: The sodium chloride sodium phosphate concentration of 0.9% sodium chloride injection compatibility, respectively, in the dark conditions and simulated non-dark conditions of clinical 0,1,2,4,8,24 hour efficient Liquid chromatography determination of content, and comparative analysis of different conditions, the results of different time periods. Results: Riboflavin sodium phosphate was stable within 24 hours under dark conditions. The compatibility solution gradually degraded with the increase of time under simulated non-dark conditions. Conclusion: Riboflavin sodium phosphate is unstable to light. During clinical infusion, it is necessary to take effective measures to avoid light to improve the quality of infusion.