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抽动-秽语综合征(TS)主要由氟哌啶醇治疗,80%有效,但2/3病人因付作用而不能坚持长期治疗。自1979年应用可乐宁(clonidine)治疗本病以来,有5篇报导50%以上有效,有两篇报导仅20%或少数患者有效。本文报告用单盲法安慰剂对照观察可乐宁20周及一年的疗效及安全性。本组男12,女1,年龄9～16岁。按DSMⅢ标准确诊。停止治疗至少2月后入院,先行单盲法短程安慰剂对照试验20周,开始随机选用安慰剂1～3周后给可乐宁8周,然后再给安慰剂2周后给可乐宁8周。起用或停用可乐宁时渐增或渐减5～10天。平均剂量为每天5.5mg/kg。药片成分对病人、家属及助手均保密。继之,行开放式长程治疗,剂量按需要而定,疗效由专家定期判定。单盲安慰剂对照试验结果:按本病完全记分法(TSGS),在第1和第2个8周时,分别平均减少28%和33%。声音抽搐较运动抽搐疗效显著,前者
Tourette’s syndrome (TS) is predominately treated with haloperidol at 80%, but 2/3 of patients do not adhere to long-term treatment due to their role. Since clonidine was used in the treatment of this disease in 1979, there are 5 reports of more than 50% effective, with two reports reported to be effective in only 20% or a few patients. This article reports the single-blind placebo-controlled placebo for 20 weeks and one year of efficacy and safety. The group of male 12, female 1, aged 9 to 16 years old. According to DSM Ⅲ standard diagnosis. Patients were admitted to hospital at least 2 months after discontinuation of treatment. Patients were given a single-blinded, short-course, placebo-controlled trial for 20 weeks. Randomized placebo was given for 1 to 3 weeks followed by 8 weeks for clonidine and then to placebo for 2 weeks. Use or disable clonidine gradually increase or decrease 5 to 10 days. The average daily dose is 5.5 mg / kg. The composition of the pills is confidential to patients, their families and assistants. Followed by open long-term treatment, the dose according to need, efficacy regularly determined by experts. Results from a single-blind placebo-controlled trial: An average reduction of 28% and 33% at Week 1 and 2, respectively, according to TSGS. Acoustic twitch than the movement of convulsions significant effect, the former