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目的探讨氨基末端脑钠肽前体(NT-proBNP)在鉴别诊断急诊呼吸困难中的临床意义。方法选择2009年6月—2011年6月在我院进行治疗的急诊呼吸困难患者256例,均采用酶联免疫吸附测定(ELISA)法检测血浆NT-proBNP水平,其中包括132例慢性心力衰竭(CHF)引起的呼吸困难,124例非CHF引起的呼吸困难,比较两组患者血浆中NT-proBNP水平的差异。结果 CHF组与正常对照组血浆NT-proBNP水平比较,差异有统计学意义(t=25.8128,P<0.01);CHF组与非CHF组血浆NT-proBNP水平比较,差异有统计学意义(t=21.4199,P<0.01)。不同心功能级别的CHF患者血浆NT-proBNP水平比较,差异有统计学意义(P<0.05)。结论血浆NT-proBNP水平是鉴别诊断CHF引起呼吸困难的有效指标,能够快速简单和特异敏感地诊断心力衰竭。
Objective To investigate the clinical significance of NT-proBNP in the differential diagnosis of emergency dyspnea. Methods Totally 256 patients with acute dyspnea who were treated in our hospital from June 2009 to June 2011 were enrolled in this study. Plasma NT-proBNP levels were measured by enzyme linked immunosorbent assay (ELISA), including 132 patients with chronic heart failure CHF), dyspnea in 124 non-CHF patients, and to compare the plasma levels of NT-proBNP between the two groups. Results The plasma levels of NT-proBNP in CHF group were significantly higher than those in normal control group (t = 25.8128, P <0.01). The plasma levels of NT-proBNP in CHF group and non-CHF group were significantly different (t = 21.4199, P <0.01). The levels of plasma NT-proBNP in CHF patients with different cardiac function levels were significantly different (P <0.05). Conclusion The plasma NT-proBNP level is an effective marker for the differential diagnosis of dyspnea induced by CHF, which can diagnose heart failure quickly and easily.