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Haloprogin(3-碘-2-丙炔基2,4,5-三氯苯基醚)是一种外用抗真菌、抗念珠菌和抗细菌的广谱抗菌药,为测定其临床使用的安全性,作者用含本品1%的乳膏(霜)作了如下几项试验: 1.皮肤刺激性试验:给20例密封贴敷乳膏,每天1次,共10～20天后,作斑贴试验。试验前后作血、尿常规检查,用药10天者在试验前和试验期均检查肝、肾和甲状腺功能。结果未发现明显的皮肤刺激和其他毒性反应。 2.皮肤接触性致敏试验:22例的前臂部先用5%硫酸月桂基钠水溶液处理24小
Haloprogin (3-iodo-2-propynyl 2,4,5-trichlorophenyl ether) is a topical antibacterial, anti-Candida and antibacterial broad-spectrum antimicrobial agent for the determination of its clinical safety , The author with the product containing 1% cream (cream) made the following several tests: 1. Skin irritation test: to 20 cases sealed cream, 1 day, a total of 10 to 20 days after the patch test. Before and after the test for blood, urine routine examination, medication for 10 days before and during the test were checked liver, kidney and thyroid function. No significant skin irritation and other toxic effects were found. 2. Skin sensitization test: 22 cases of forearm with 5% sodium lauryl sulfate solution for 24 hours