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观察维生素K对P－乙酰氨基酚（500mg／kg）灌胃所致小鼠肝损伤的影响。结果表明：维生素K能减轻P－乙酰氨基酚引起的小鼠血清丙氨酸转氨酸（SALT）活性升高和肝糖原含量的下降以及肝损伤的病理性变化。维生素K也能降低P－乙酰氨基酚（1000mg／kg）灌胃所致的小鼠死亡率，但差异没有显著性（P＞0．05）。上述作用维生素K3均比维生素K1强。
To observe the effect of vitamin K on hepatic injury caused by intragastric administration of P-acetaminophen 500 mg / kg. The results showed that: vitamin K can reduce P-acetaminophen-induced mouse serum alanine aminotransferase (SALT) activity and hepatic glycogen content decreased, as well as the pathological changes of liver injury. Vitamin K also reduced the mortality of mice caused by intragastric administration of P-acetaminophen (1000mg / kg), but the difference was not significant (P> 0.05). The role of vitamin K3 are stronger than vitamin K1.