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慢性骨软化的组织学损害与缺乏维生素D者相似,也是维生素D代谢异常所致。人体内1,25-双羟基维生素D_3(1,25-(OH)_2D_3)是由肝内25-羟基维生素D_3(26-OHD_3)转变而来,肾脏是利用25-羟基维生素D_3制造1,25-双羟基维生素D_3的唯一部位。慢性肾衰患者,其血浆1,25-(OH)_2D_3水平较低。过去认为这些患者的骨软化是缺乏1,25-(OH)_2D_3的假设不能令人满意。因为在有些没有1,25-(OH)_2D_3的患者(无肾的透析患者及双肾切除的患者),在术后6年仍未
Chronic osteomalacia histological damage and lack of vitamin D are similar, but also due to abnormal vitamin D metabolism. 1,25- dihydroxy vitamin D_3 (1,25- (OH) _2D_3) in the human body is derived from the intrahepatic 25-hydroxyvitamin D_3 (26-OHD_3), and the kidney is made from 25-hydroxyvitamin D_3 - The only site of bishydroxy vitamin D_3. In patients with chronic renal failure, the plasma 1,25- (OH) _2D_3 levels are low. In the past, the assumption that osteopenia in these patients was deficient in 1,25- (OH) _2D_3 was unsatisfactory. Because in some patients without 1,25- (OH) _2D_3 (dialysis patients without kidney and patients with double-nephrectomy), 6 years after surgery have not yet