近来,卵巢瘤的发病率有增加的倾向。本次想仅就近五年间作者对卵巢肿瘤患者的内分泌环境及上皮性卵巢肿瘤产生雌激素的原理所进行的探讨加以叙述。一、关于上皮性卵巢瘤产生的雌激素1.绝经后的高雌激素状态众所周知,随着卵巢功能的衰退,雌激素的分泌也日渐减少。绝经后的高雌激素状态,除功能性卵巢瘤外,一般认为是由肾性脱氢表雄酮在脂肪细胞中转化成雌酮引起的。因而对肥胖引起了注意。1960年以阴道涂片首次发现了卵巢肿瘤引起的高雌激素状态。另有报告,绝经后卵巢瘤患者的尿及血中的雌激素均升高。本教研室从1981年开始对卵巢 Recently, the incidence of ovarian cancer tends to increase. This time to think about only the past five years, the author of ovarian cancer patients with endocrine environment and epithelial ovarian tumors to produce estrogen the principle of the discussion to be described. First, on the production of epithelial ovarian tumor estrogen 1. Postmenopausal high estrogen state is well known, with the decline of ovarian function, estrogen secretion is also decreasing. Postmenopausal high estrogen status, in addition to functional ovarian cancer, is generally considered to be caused by the conversion of renal DHEA to estrone in adipocytes. This has drawn attention to obesity. For the first time in 1960, vaginal smear found ovarian tumors caused by high estrogen status. Another report, postmenopausal ovarian cancer patients with urinary and estrogen levels were elevated. The Department started from 1981 on the ovary