脓毒症的心血管影响在一些病人中导致被称为高动力的状态,心排出量增加,周围血管阻力减少。这些影响反映在肾脏则表现为肾脏血流量增加,肾血管阻力减少。临床上出现多尿型肾衰,即使限制液体,仍有多尿并可能导致低血容量。多尿的病因从前归诸于渗透性利尿,但以后证明此说错误。其后又假设为肾髓质血流量增加的结果,但缺乏直接证明。本研究用放射性微球体技术测定脓毒症时肾内血流量的改变,通过物动实验证实了脓毒症情况下肾血流量增加的理 The cardiovascular effects of sepsis result in what is called high motility in some patients, with increased cardiac output and reduced peripheral vascular resistance. These effects are reflected in the kidneys showed increased renal blood flow, decreased renal vascular resistance. Polyuric renal failure clinically, even if the liquid limit, there is still polyuria and may lead to hypovolemia. The etiology of polyuria has historically been attributed to osmotic diuresis, but later proof of this error. It was later assumed to be an increase in renal medullary blood flow, but lack of direct evidence. In this study, radioactive microspheres were used to measure changes of renal blood flow in sepsis. The animal experiments confirmed the increase of renal blood flow in sepsis