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作者报道1例慢性骨髓单核细胞白血病(CMMoL),其最初骨髓直接制片核型正常,一年后发展为急性骨髓白血病(AML)时,发现其15号染色体长臂出现克隆空隙缺失。据作者所知,这种染色体异常作为CMMoL、AML或其它人类恶性肿瘤的唯一异常以前尚未报道。患者,男,70岁,贫血,临床检查未发现淋巴结病和肝脾肿大。骨髓检查呈CM-MoL改变,未成熟细胞增加(14%),细胞免疫化学和电子显微镜检查进一步证实上述诊断。这一时期的细胞遗传学分析显示骨髓核型正常。经定期输血治疗及两个疗程的化疗,约10个月后,患者出现肝脾肿大,白细胞计数和未成熟细胞急剧增加,骨髓检查证
The authors report a case of chronic myelomonocytic leukemia (CMMoL), the initial direct production of bone marrow normal karyotype, a year later to the development of acute myeloid leukemia (AML), found that the long arm of chromosome 15 appeared clonal voids. To the authors’ knowledge, this chromosomal abnormality has not been previously reported as the only abnormality in CMMoL, AML or other human malignancies. Patients, male, 70 years old, anemia, clinical examination found no lymphadenopathy and hepatosplenomegaly. Bone marrow examination showed changes in CM-MoL, immature cells increased (14%), cellular immunochemical and electron microscopy to further confirm the above diagnosis. Cytogenetic analysis during this period showed normal karyotype of bone marrow. After a regular blood transfusion and two courses of chemotherapy, about 10 months later, the patient developed hepatosplenomegaly, a sharp increase in white blood cell count and immature cells, and a bone marrow examination certificate