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目的:观察支气管哮喘患儿肺功能状态及Th1Th2指标的变化情况。方法:选取2013年10月~2015年8月本院诊治的65例支气管哮喘患儿为观察组,另选择同期接受体检的健康同龄儿童65名为对照组。比较两组患儿肺功能状态及Th1Th2指标,观察不同严重程度及分期支气管哮喘患儿的肺功能状态及Th1Th2指标。结果:观察组患儿肺功能指标及血清Th1Th2指标均低于对照组,差异具有统计学意义(P<0.05);观察组患儿发作期肺功能指标及血清Th1Th2指标明显低于缓解期,差异具有统计学意义(P<0.05);重度患儿肺功能指标及血清Th1Th2指标均低于轻度及中度患儿,差异具有统计学意义(P<0.05);中度患儿肺功能指标及血清Th1Th2指标低于轻度患儿,差异具有统计学意义(P<0.05)。结论:支气管哮喘患儿肺功能状态及Th1Th2指标的变化较大,且疾病分期与疾病严重程度对其检测结果也有较大影响。
Objective: To observe the change of pulmonary function status and Th1 Th2 index in children with bronchial asthma. Methods: 65 children with bronchial asthma treated in our hospital from October 2013 to August 2015 were selected as the observation group, and 65 healthy children of the same age undergoing physical examination were selected as the control group. The pulmonary function status and Th1Th2 index were compared between the two groups to observe the pulmonary function status and Th1Th2 index in children with different severity and stage of bronchial asthma. Results: The indexes of lung function and serum Th1Th2 in the observation group were lower than those in the control group (P <0.05). The indexes of pulmonary function and serum Th1Th2 in the observation group were significantly lower than those in the remission stage (P <0.05). The indexes of lung function and serum Th1Th2 in children with severe disease were lower than those in mild and moderate children (P <0.05) The serum Th1Th2 index was lower than mild children, the difference was statistically significant (P <0.05). Conclusion: The changes of pulmonary function status and Th1Th2 index in children with bronchial asthma are great, and the staging of the disease and the severity of the disease also have a great impact on the test results.