一般认为血锂浓度在治疗范围时,锂对肾脏的影响仅系功能性的,停药后可以恢复。近有报告认为锂可导致肾脏浓缩功能持久性缺损,锂维持治疗时可引起慢性间质性肾炎和肾功能不全。锂引起肾功能可逆性改变钠的平衡:由于锂可减少钠在近曲小管、远曲小管和集合管的重吸收,故可增加钠的排出,但一般系暂时而轻度的。在某些临床 Generally considered the blood lithium concentration in the treatment range, the impact of lithium on the kidney is only functional, after stopping can be restored. Nearly reports that lithium can lead to permanent loss of renal function, lithium maintenance therapy can cause chronic interstitial nephritis and renal insufficiency. Lithium causes renal function Reversible changes in the balance of sodium: Because lithium can reduce sodium reabsorption of proximal convoluted tubules, distal convoluted tubules and collecting tubes, it is possible to increase sodium excretion, but generally it is temporary and mild. In some clinics