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虽然已报道了200多例新生儿红斑狼疮(NLE),但有关该病的预后、临床特点及遗传背景仍不清楚,似乎不同种族间症状有差异。对日本几家大医院60例 NLE 患儿(男23例,女37例)的预后、临床特点及母亲情况进行研究,发现日本 NLE 的临床特点与文献报道的有不同之处。NLE 皮疹大部分在生后1月内出现,18%出生时即有皮疹。皮疹类型:DLE 样皮疹、环形红斑、紫癜及口炎者分别为20%,67%,5%及2%,5例有 SLE 的皮疹表现。另有10%
Although more than 200 cases of newborn lupus erythematosus (NLE) have been reported, the prognosis, clinical features, and genetic background of the disease remain unclear and it appears that there are differences between different ethnic groups. The prognosis, clinical features and maternal status of 60 NLE children (male 23, female 37) in several major hospitals in Japan were studied. The clinical features of Japanese NLE were found to be different from those reported in the literature. The majority of NLE rashes occur within 1 month of birth, with a rash of 18% at birth. Rash types: DLE-like rash, erythema ring erythematosus, purpura and stomatitis were 20%, 67%, 5% and 2%, 5 cases of SLE rash. Another 10%