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本文对63例绝经前切除子宫者,与正常同龄者、自然绝经者进行了对照研究。发现切除子宫者即使保留了卵巢,也有卵巢功能早衰的表现,如更年期综合征的提前出现,体重指数(BMI)增加,生殖激素测定可见垂体激素水平升高,卵巢内优势卵泡减少等。对血中脂蛋白及载脂蛋白研究表明,术后不同年龄及年限均有血脂代谢紊乱的现象,某些致动脉硬化的脂类浓度也高,抗动脉硬化的脂类浓度减低。血中血管活性物质前列腺环素(PGI_2)及血栓素(TXA_2)手术后水平均升高,二者关系密切,反应了PGI_2随TXA_2升高有代偿性作用,以防对心血管损害。根据血中脂质及前列腺素的研究,提示绝经前切除子宫,可能导致冠心病的发病率增加。
In this paper, 63 cases of premenopausal uterine resection, and normal age, natural menopause were compared. Found that the removal of the uterus, even if retained the ovary, ovarian function also showed premature aging, such as the early appearance of menopausal syndrome, body mass index (BMI) increased, reproductive hormones showed increased levels of pituitary hormone, ovarian follicles reduced the dominant. Studies on blood lipoproteins and apolipoproteins showed that dyslipidemias were disordered at different ages and years postoperatively. Some atherosclerosis also had high concentrations of lipids and atherosclerosis-resistant lipids. PGI_2 and TXA_2 in blood were increased after operation, which showed that PGI_2 had a compensatory effect as TXA_2 increased to prevent cardiovascular damage. According to blood lipid and prostaglandin research, suggesting that premenopausal uterine resection, may lead to an increased incidence of coronary heart disease.