A pseudo-one-dimensional model comprising different coaxial mixing is proposed for the study of the liquid phase mixing in packed column. The model parameters are estimated by the optimal method of nonlinear programming, and the equivalent mixing coefficient is regressed in the form of dimensionless equation. A pseudo-one-dimensional model includes different coaxial mixing is proposed for the study of the liquid phase mixing in packed column. The model parameters are estimated by the optimal method of nonlinear programming, and the equivalent mixing coefficient is regressed in the form of dimensionless equation.