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肉苁蓉是弛名的壮阳中药。作者曾从其分得一环烯醚萜葡萄糖甙——8-表马钱甙酸和一单萜烯葡萄糖甙——8-羟基(牜龙)牛儿醇-β-D-葡萄糖甙。本文续报从其又分得D-甘露醇、β-谷甾醇、琥珀酸、β-谷甾醇-β-D-葡萄糖甙等四个已知的化合物和两个新的、被分别命名为肉苁蓉素和肉苁蓉氯素的环烯醚萜化合物,并根据化学和光谱数据确定了它们的结构。提取分离:取中国产干燥肉苁蓉(全草)用甲醇回流提取。然后,将提取液在减压下浓缩、残渣悬于水中,依次用乙酸乙酯和水饱和的正丁醇萃取。将乙酸乙酯萃取物经硅胶柱层析,得到两个组分。将其中之一用甲醇结晶后得到β-谷甾醇。另一组分用硅胶柱层析后得到肉苁蓉氯素(150mg)。
Cistanche is a reputed aphrodisiac Chinese medicine. The authors have been assigned to an iridoid glucoside, 8-premaliphatic acid and a monoterpene glucoside, 8-hydroxy-steroidal zein-β-D-glucoside. This article continues to report that four other known compounds, namely D-mannitol, β-sitosterol, succinate, and β-sitosterol-β-D-glucoside, have been assigned, and two new ones have been named Cistanche. Cyclic ether glycosides of phytocin and cistanche, and their structures were determined based on chemical and spectral data. Extraction and separation: take Cistanche deserticola (whole grass) produced in China with methanol reflux extraction. Then, the extract was concentrated under reduced pressure, the residue was suspended in water, and sequentially extracted with ethyl acetate and water-saturated n-butanol. The ethyl acetate extract was chromatographed on silica gel to give two components. One of these was crystallized from methanol to give [beta]-sitosterol. The other fraction was subjected to silica gel column chromatography to obtain celcius chloride (150 mg).