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In clinical, β-blockers (e.g., metoprolol tartrate (ME)), calcium channel blockers (e.g., diltiazem hydrochloride (DL)) and nitrates (e.g., isosorbide mononitrate (ISMN)) have been used in cardiovascular diseases and ME, DL and ISMN (Fig 1) are common drugs to cure angina.In order to improve the curative effect, the angina is treated by drug combinations in general [1].In order to design a personal treatment plan for individuals, it is necessary to establish a sensitive and fast analytical method to determine these analytes in angina patients serum.