柚皮素对K562/A02细胞MDR1 mRNA/P-gp的影响研究

来源 :中国工程院2014年医学科学前沿论坛第十四次全国临床药理学学术会议暨第六届国际药物警戒与药物安全学术会议 | 被引量 : 0次 | 上传用户：ssttll

【摘要】

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目的:研究柚皮素对K562/A02细胞MDR1 mRNA及P-gp表达的影响及其分子生物学机制.方法:以NF-κB特异性抑制剂吡咯烷二硫代氨基甲酸盐(Pyrrolidine dithiocarbamate,PDTC,25μM)为阳性对照组,将不同浓度柚皮素(50、100、250、500μM)单独或联合阿霉素(5μM)作用于K562/A02细胞48h,RT-PCR法检测MDR1 mRNA的表达水平,

【作者】

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朱宏平李新华靳高凤熊玉卿夏春华张红黄世博

【机构】

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南昌大学临床药理研究所/江西省临床药物代谢动力学重点实验室,330006 南昌大学医院,江西南昌,

【出处】

：

中国工程院2014年医学科学前沿论坛第十四次全国临床药理学学术会议暨第六届国际药物警戒与药物安全学术会议

【发表日期】

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2014年3期

【关键词】

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柚皮素 K562/A02细胞 MDR1 mRNA P-gp NF-κB

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柚皮素对K562/A02细胞MDR1 mRNA/P-gp的影响研究

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